Two sample MR report
CST3_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0089196 | 0.0845385 | 0.9185692 |
| Weighted median | 10 | -0.0300565 | 0.0101766 | 0.0031421 |
| Inverse variance weighted | 10 | -0.0308227 | 0.0083224 | 0.0002126 |
| Simple mode | 10 | -0.0297225 | 0.0145240 | 0.0710223 |
| Weighted mode | 10 | -0.0299603 | 0.0160287 | 0.0944240 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2622022 | 8 | 0.9999889 |
| Inverse variance weighted | 0.4853681 | 9 | 0.9999732 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0225637 | 0.0477636 | 0.6492568 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003777 | 0 | TRUE | 0.0645957 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
